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7 Best Cat Urine & Odor Removers (Enzyme Cleaners 2021) – Reviews & Top Picks

Ed Malaker

Cat peed on sofa

If you have a cat, you know that they can go outside the box on occasion, and it can be challenging to remove the odors once they set in. Enzyme cleaners work well to remove smells by destroying the organic material that creates them. However, with so many different enzyme cleaners available, it can be challenging to find a brand that is non-toxic and effective at removing scents. We have chosen several different kinds to review for you so you can see the difference between them. We’ll give you the pros and cons of each one and tell you how they worked in our home. Keep reading while we look at package size, ingredients, effectiveness, and more to help you make an educated purchase.

A Quick Comparison of Our Favorites

Image Product Details
Best Overall
Winner
Simple Solution Stain & Odor Remover Simple Solution Stain & Odor Remover
  • Bacteria and enzymes
  • Safe to use around children and pets
  • Designed for use on multiple surfaces
  • Best Value
    Second place
    PetSafe Wee Care Enzyme Cleaner PetSafe Wee Care Enzyme Cleaner
  • Safe to use around children and pets
  • Multi-surface cleaner
  • Eco-friendly
  • Premium Choice
    Third place
    Rocco & Roxie Stain & Odor Eliminator Rocco & Roxie Stain & Odor Eliminator
  • Safe to use around children and pets
  • Multi-surface cleaner
  • Freshens fabric
  • Best Cleaner for Urine
    Best Carpet Cleaner for Cat Urine Best Carpet Cleaner for Cat Urine
  • Non-toxic
  • Multi-surface cleaner
  • Available in multiple sizes
  • Best Enzymatic Urine Remover
    Nature’s Miracle Stain & Odor Remover Nature’s Miracle Stain & Odor Remover
  • Odor locking technology
  • Eliminates deep-set in odors
  • No rinsing
  • The 7 Best Urine and Odor Removers – Reviews & Top Picks 2021

    1. Simple Solution Pet Stain & Odor Remover with Pro-Bacteria and Enzyme Formula – Best Overall

    Simple Solution Stain Remover

    Size: 1 quart
    Fragrance: Unscented

    Simple Solution Pet Stain & Odor Remover with Pro-Bacteria and Enzyme Formula is our pick as the best overall cat urine and odor remover. It uses both bacteria and enzymes to help destroy organic material and odors. It’s non-toxic and safe to use around children and pets. It uses a special formula that works on multiple surfaces, including carpets, upholstery, bedding, clothing, and more.

    The downside to Simple Solution Pet Stain & Odor is that it can take more than one application to remove the urine smell.

    Pros
    • Bacteria and enzymes
    • Safe to use around children and pets
    • Designed for use on multiple surfaces
    Cons
    • It doesn’t always get out the urine smell

    2. PetSafe Pet Loo Wee Care Enzyme Cleaner – Best Value

    PetCare Wee Care Enzyme Cleaner

    Size: 16 ounces
    Fragrance: No Fragrance

    PetSafe Pet Loo Wee Care Enzyme Cleaner is our pick as the best cat urine and odor remover for the money. It’s safe to use around children and other pets and is also safe for the environment. It works on multiple surfaces and contains no fragrance, so it’s perfect for people with sensitivities.

    We found that PetSafe Pet Loo Wee Care Enzyme Cleaner works well, but the small bottle runs out quickly.

    Pros
    • Safe to use around children and pets
    • Multi-surface cleaner
    • Eco friendly
    Cons
    • Might discolor fabric

    3. Rocco & Roxie Supply Co. Professional Strength Pet Stain & Odor Eliminator – Premium Choice

    Rocco & Roxie Stain & Odor Eliminator

    Size: 1 quart
    Fragrance: Yes

    PetSafe Pet Loo Wee Care Enzyme Cleaner is our pick as the premium cat urine and odor remover. It is a non-toxic cleaner that is safe to use around children and pets, and it has a nice odor that will leave your room smelling better. You can use it on multiple surfaces like fabric, carpet, and furniture, and it’s easy to apply using the handy spray bottle.

    The only negative things we can say about PetSafe Pet Loo Wee Care was that it didn’t prevent our cats from returning to the same place we had already cleaned, and the container was flimsy and tended to leak., so we lost a lot of product.

    Pros
    • Safe to use around children and pets
    • Multi-surface cleaner
    • Freshens fabric
    Cons
    • Leaky bottle

    4. MisterMax Anti-Icky-Poo – Best Carpet Cleaner for Cat Urine

    MasterMax Anti Icky Poo

    Size: 1 quart
    Fragrance: Scented and unscented

    MisterMax Anti-Icky-Poo is our choice as the best carpet cleaner for cat urine. This brand is available in many sizes up to one gallon, and you can purchase it scented or unscented. It’s non-toxic and safe to use around children and pets, and you can use it on all surfaces. We found it especially useful on the carpet because you can treat a large area.

    While enzymes often require more than one treatment to eliminate everything, we found MisterMax Anti-Icky-Poo to take more applications than the ones we looked at so far.

    Pros
    • Non-toxic
    • Multi-surface cleaner
    • Available in multiple sizes
    Cons
    • Requires multiple applications

    5. Nature’s Miracle Dual Action Hard Floor Stain & Odor Remover – Best Enzymatic Cat Urine Remover

    Nature's Miracle Hard Floor Cleaner

    Size: 24 ounce
    Fragrance: Yes

    Nature’s Miracle Dual Action Hard Floor Stain & Odor Remover is our pick as the best enzymatic urine remover. We found that its odor locking technology does an excellent job of getting rid of urine odors and is has a special formula that works well on hard surfaces like concrete, brick, tile, and more, where other brands can struggle. The convenient spray bottle makes it easy to apply, and there is no need for rinsing.

    The downside to Nature’s Miracle is that it contains a fragrance that we didn’t like, and we think many people will agree that it smells bad, and though it does an excellent job cleaning, our cats still return to the same spot to urinate again.

    Pros
    • Odor locking technology
    • Eliminates deep-set in odors
    • No rinsing
    Cons
    • Smells bad
    • Cats return to the same spot

    You might also be interested in: 10 Natural and Safe Home Remedies to Keep Cats Away


    6. Nature’s Miracle Cat Enzymatic Urine Destroyer – Best Cat Urine Remover for Carpet

    Nature's Miracle Urine Destroyer

    Size: 1 gallon
    Fragrance: Yes

    Nature’s Miracle Cat Enzymatic Urine Destroyer is our pick as the best cat urine remover for carpet. It comes in a large 1-gallon container so that you won’t run out in the middle of a job. It can remove deep-set stains and starts to work almost immediately while remaining safe to use around children and pets. We noticed a difference just a few minutes after applying it.

    The biggest downside to Nature’s Miracle Cat Enzymatic Urine Destroyer is that it leaves a powerful smell that fills the room. It also lingers for several days, and some people might not like it. It works well, but due to the fragrance, we only use it on big accidents.

    Pros
    • Multi-surface cleaner
    • Works quickly
    • Eliminates set stains
    Cons
    • Powerful smell

    7. Simple Solution Yard Odor Away – Best Urine Remover For Yards

    Simple Solution Yard Odor Awawy

    Size: 1 quart
    Fragrance: Yes

    Simple Solution Yard Odor Away is our pick as the best urine remover for yards. It features a very easy-to-use design that allows you to connect the container directly to your garden hose for the perfect mix. Each 32-ounce container can control odors over 25,000 square feet, more than enough for most homes. You can also use it on other surfaces like your porch, deck, sidewalks, and lawn furniture.

    The downside to Simple Solution is that it contains mild detergents that can irritate the eyes, so we can’t recommend using it around pets or children. Since the container only connects to the garden hose, it’s strictly for outdoor use.

    Pros
    • Treats up to 25,000 square feet
    • Easy to use
    • Multi-surface
    Cons
    • Contains detergent
    • Not for use around pets

    Related Read: How to Get Cat Pee Smell Out of a Couch (3 Quick & Easy Methods)

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    Buyer’s Guide

    What Are Enzyme Cleaners?

    Enzymes are helpful bacteria that consume starch, oil, fat, protein, and other organic matter. While not all strains contain these elements, many of them do, and enzyme cleaners can help break them down, removing stains that would not be possible with traditional detergents. The slow breakdown of organic material is the source of many foul odors found in the home, and enzyme cleaners can help remove them.

    What Can You Clean with Enzyme Cleaners?

    Enzyme cleaners work perfectly for removing urine, feces, vomit, blood, and anything else that comes from a living thing. It also works well to remove food stains and sometimes removes the most difficult stains, like wine and blood. Enzyme cleaners also work well to eliminate grease and oil, and many restaurants use them in their floor cleaners.

    Is There a Downside to Enzyme Cleaners?

    Can Eat Away at Some Surfaces

    The downside to enzyme cleaners is that they can eat away at certain surfaces if used too frequently. For instance, restaurants that use enzymes daily will notice that they can eat away at the grout between tiles, so it might not be a great choice for a floor with many small tiles. However, the process is extremely slow and only a concern if you are applying the enzymes several times a day for a long period.

    Works Slowly

    Most people expect to apply a product, rub it around a little, wipe it up and have a clean surface, but that isn’t how enzymes work. Enzymes are living bacteria that spend their lives snacking on your stain. It takes time for them to eat it, and they may die before they finish because they have a relatively short lifespan.

    With enzymes, you apply them and keep checking back every few hours. The stain should fade, and you will need to reapply it every 24 hours until it’s gone.

    What Is the Benefit of Enzyme Cleaners?

    Many stains can penetrate the fabric and become locked, unable to be dislodged by traditional detergents. These detergents frequently contain chemicals that can be harmful to your pet or yourself. Enzymes, on the other hand, are microscopic living bacteria that will eat the stain before dying. These bacteria are not harmful to people or pets, and they have a short lifespan. They don’t create any odor or leave any residue behind that you need to rinse.

    What Makes One Brand Better Than Another?

    The primary thing that makes one brand better than another is the concentration of enzymes in the bottle. As the enzymes eat, they die, so if there are only a few, you will need to reapply it several times before your stain comes out. Unfortunately, there is no way to tell how concentrated most brands are, so you will need to resort to trial and error and reviews like these. Since many brands have limited ingredients, you can often guess the concentration based on cost.

    You might also be interested in: Cat Peeing Outside Litter Box? 11 Reasons and How to Stop It

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    Conclusion

    When choosing your next enzyme cleaner, we highly recommend our pick as the best overall. Simple Solution Pet Stain & Odor Remover with Pro-Bacteria and Enzyme Formula provides you with multiple enzymes for improved cleaning performance. The 32-ounce package should be more than suitable for most pet owners that have occasional accidents. If your pet rarely has an accident and you are looking for something small for a single accident, we recommend our pick for the best value. The PetSafe Pet Loo Wee Care Enzyme Cleaner comes in a small eco-friendly package and should eliminate your stain or odor without breaking the bank.

    We hope you have enjoyed reading over these reviews and found them helpful in answering your questions. If you have found a few brands you would like to try, please share these seven best cat urine and odor removers on Facebook and Twitter.


    Featured Image Credit: cunaplus, Shutterstock

    Ed Malaker

    Ed Malaker is a veteran writer who has contributed to a wide range of blogs that cover tools, pets, guitars, fitness, and computer programming. When he’s not writing, Ed is usually performing DIY projects around the house or working in the garden. He’s also a musician and spends a lot of time helping people fix their guitars and composing music for independent films.