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Home > Cats > 8 Best Cat Urine, Odor & Stain Removers in 2024 – Reviews & Top Picks

8 Best Cat Urine, Odor & Stain Removers in 2024 – Reviews & Top Picks

A person's hand spraying a gray couch with a cat urine removal spray bottle

If you have a cat, you know that they can go outside the box on occasion, and it can be challenging to remove the odors once they set in. Enzyme cleaners work well to remove smells by destroying the organic material that creates them. However, with so many different enzyme cleaners available, it can be challenging to find a brand that is non-toxic and effective at removing scents. We have chosen several different kinds to review for you so you can see the difference between them. We’ll give you the pros and cons of each one and tell you how they worked in our home. Keep reading while we look at package size, ingredients, effectiveness, and more to help you make an educated purchase.

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A Quick Look At The Winners in 2024

Image Product Details
Best Overall
Winner
Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray
  • Gets the toughest jobs done
  • Dissolves stains and eliminates odors
  • Works on other scents like feces and vomit
  • Budget Buy
    Second place
    PetSafe Wee Care Enzyme Cleaner PetSafe Wee Care Enzyme Cleaner
  • Safe to use around children and pets
  • Multi-surface cleaner
  • Eco-friendly
  • Third place
    R&R Stain & Odor Eliminator R&R Stain & Odor Eliminator
  • Safe to use around children and pets
  • Multi-surface cleaner
  • Freshens fabric
  • MisterMax Anti-Icky-Poo MisterMax Anti-Icky-Poo
  • Non-toxic
  • Multi-surface cleaner
  • Available in multiple sizes
  • Nature’s Miracle Stain Remover Nature’s Miracle Stain Remover
  • Odor locking technology
  • Eliminates deep-set in odors
  • No rinsing
  • The 8 Best Cat Urine, Odor & Stain Removers

    1. Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray – Best Overall

    hepper enzyme cleaner spray

    Size: 32 oz
    Fragrance: Neutral

    Hepper’s Advanced Bio-Enzyme Pet Stain and Odor Eliminator formula is our pick as the best overall cat urine odor remover. This spray is an extremely effective and eco-conscious product that works to bind, lift, and remove even the most offensive urine smells. The bio-enzymatic formula isn’t just for cat urine, either. You can use it on drool, vomit, feces, and other substances, too.

    This spray is simple to use. There’s no need to mix it with water. You just shake the bottle and spray it on the soiled area. The bio-enzymes will get to work right away to penetrate the area to both dissolve the stain and remove the odor at its source.

    This cleaning spray is tough on stains and odors but won’t harm the surfaces in your home. It has been tested on carpets, flooring, fabrics, and furniture. Of course, you’ll want to perform a colorfastness test to be sure, but we loved how versatile this formula is.

    Another attractive feature of this spray is its neutral scent. Other odor eliminators on the market claim to remove odors at the source but instead just mask them with overpowering scents in their formulas. This spray, however, is void of any chemical fragrances so when the urine smell is gone, you know it’s gone for good and not just hiding behind perfumes.

    At Pet Keen, we’ve admired Hepper for many years and decided to take a controlling ownership interest so that we could benefit from the outstanding designs of this cool cat company!

    Pros
    • No mixing required
    • Dissolves stains and removes odors
    • 100% satisfaction guarantee
    • Affordable price tag
    • Works for other scents like feces and vomit
    Cons
    • The product has to sit on the stain for an hour or more to work effectively

    2. PetSafe Pet Loo Wee Care Enzyme Cleaner – Budget Buy

    PetCare Wee Care Enzyme Cleaner

    Size: 16 ounces
    Fragrance: No Fragrance

    PetSafe Pet Loo Wee Care Enzyme Cleaner is our pick as the best cat urine and odor remover for the money. It’s safe to use around children and other pets and is also safe for the environment. It works on multiple surfaces and contains no fragrance, so it’s perfect for people with sensitivities.

    We found that PetSafe Pet Loo Wee Care Enzyme Cleaner works well, but the small bottle runs out quickly.

    Pros
    • Safe to use around children and pets
    • Multi-surface cleaner
    • Eco friendly
    Cons
    • Might discolor fabric
    • Runs out quickly

    3. Rocco & Roxie Supply Co. Professional Strength Pet Stain & Odor Eliminator

    Rocco & Roxie Stain & Odor Eliminator

    Size: 1 quart
    Fragrance: Yes

    Rocco & Roxie Supply Co. Professional Strength Pet Stain & Odor Eliminator is another great premium product. It is a non-toxic cleaner that is safe to use around children and pets, and it has a nice odor that will leave your room smelling better. You can use it on multiple surfaces like fabrics, carpet, and furniture, and it’s easy to apply using the handy spray bottle.

    The only negative things we can say about Rocco & Roxie Supply Co. Professional Strength Pet Stain & Odor Eliminator were that it didn’t prevent our cats from returning to the same place we had already cleaned, and the container was flimsy and tended to leak, so we lost a lot of product.

    Pros
    • Safe to use around children and pets
    • Multi-surface cleaner
    • Freshens fabric
    Cons
    • Leaky bottle
    • Didn’t prevent cats from re-marking

    4. MisterMax Anti-Icky-Poo

    MasterMax Anti Icky Poo

    Size: 1 quart
    Fragrance: Scented and unscented

    MisterMax Anti-Icky-Poo is a great carpet cleaner for cat urine. This brand is available in many sizes up to 1 gallon, and you can purchase it scented or unscented. It’s non-toxic and safe to use around children and pets, and you can use it on all surfaces. We found it especially useful on carpet because you can treat a large area.

    While enzymes often require more than one treatment to eliminate everything, we found MisterMax Anti-Icky-Poo to take more applications to get rid of cat urine odor than the ones we looked at so far.

    Pros
    • Non-toxic
    • Multi-surface cleaner
    • Available in multiple sizes
    Cons
    • Requires multiple applications

    5. Nature’s Miracle Hard Floor Stain & Odor Remover

    Nature's Miracle Hard Floor Cleaner

    Size: 24 ounce
    Fragrance: Yes

    Nature’s Miracle Dual Action Hard Floor Stain & Odor Remover is a great enzymatic urine remover. We found that its odor-locking technology does an excellent job of getting rid of urine odors and has a special formula that works well on hard surfaces like concrete, brick, tile, and more, where other brands can struggle. The convenient spray bottle makes it easy to apply, and there is no need for rinsing.

    The downside to Nature’s Miracle is that it contains a fragrance that we didn’t like, and we think many people will agree that it smells bad. Though it does an excellent job cleaning, our cats still return to the same spot to urinate again.

    Pros
    • Odor locking technology
    • Eliminates deep-set in odors
    • No rinsing
    Cons
    • Smells bad
    • Cats return to the same spot

    6. Simple Solution Pet Stain & Odor Remover Enzyme

    Simple Solution Stain Remover

    Size: 1 quart
    Fragrance: Unscented

    Simple Solution Pet Stain & Odor Remover with Pro-Bacteria and Enzyme Formula is another decent cat urine and odor remover. It uses both bacteria and enzymes to help destroy organic material and odors. It’s non-toxic and safe to use around children and pets. It uses a special formula that works on multiple surfaces, including carpets, upholstery, bedding, clothing, and more.

    The downside to Simple Solution Pet Stain & Odor is that it can take more than one application to remove the urine smell.

    Pros
    • Bacteria and enzymes
    • Safe to use around children and pets
    • Designed for use on multiple surfaces
    Cons
    • It doesn’t always get out the urine smell

    7. Nature’s Miracle Cat Urine Destroyer

    Nature's Miracle Urine Destroyer

    Size: 1 gallon
    Fragrance: Yes

    Nature’s Miracle Cat Enzymatic Urine Destroyer is a really good option for removing cat urine from carpets. It comes in a large 1-gallon container so that you won’t run out in the middle of a job. It can remove deep-set stains and starts to work almost immediately while remaining safe to use around children and pets. We noticed a difference just a few minutes after applying it.

    The biggest downside to Nature’s Miracle Cat Enzymatic Urine Destroyer is that it leaves a powerful smell that fills the room. It also lingers for several days, and some people might not like it. It works well, but due to the fragrance, we only use it on big accidents.

    Pros
    • Multi-surface cleaner
    • Works quickly
    • Eliminates set stains
    Cons
    • Powerful smell

    8. Simple Solution Yard Odor Away – Best Urine Remover For Yards

    Simple Solution Yard Odor Awawy

    Size: 1 quart
    Fragrance: Yes

    Simple Solution Yard Odor Away is our pick as the best urine remover for yards. It features a very easy-to-use design that allows you to connect the container directly to your garden hose for the perfect mix. Each 32-ounce container can control odors over 25,000 square feet, more than enough for most homes. You can also use it on other surfaces like your porch, deck, sidewalks, and lawn furniture.

    The downside to Simple Solution is that it contains mild detergents that can irritate the eyes, so we can’t recommend using it around pets or children. Since the container only connects to the garden hose, it’s strictly for outdoor use.

    Pros
    • Treats up to 25,000 square feet
    • Easy to use
    • Multi-surface
    Cons
    • Contains detergent
    • Not for use around pets

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    Buyer’s Guide: How to Select the Best Cat Urine, Odor, and Stain Removers

    What Are Enzyme Cleaners?

    Enzymes are helpful bacteria that consume starch, oil, fat, protein, and other organic matter. While not all stains contain these elements, many of them do, and enzyme cleaners can help break them down, removing stains that would not be possible with traditional detergents. The slow breakdown of organic material is the source of many foul odors found in the home, and enzyme cleaners can help remove them.

    What Can You Clean with Enzyme Cleaners?

    Enzyme cleaners work perfectly for removing urine, feces, vomit, blood, and anything else that comes from a living thing. It also works well to remove food stains and sometimes removes the most difficult stains, like wine and blood. Enzyme cleaners also work well to eliminate grease and oil, and many restaurants use them in their floor cleaners.

    Is There a Downside to Enzyme Cleaners?

    Can Eat Away at Some Surfaces

    The downside to enzyme cleaners is that they can eat away at certain surfaces if used too frequently. For instance, restaurants that use enzymes daily will notice that they can eat away at the grout between tiles, so it might not be a great choice for a floor with many small tiles. However, the process is extremely slow and only a concern if you are applying the enzymes several times a day for a long period.

    Works Slowly

    Most people expect to apply a product, rub it around a little, wipe it up, and have a clean surface, but that isn’t how enzymes work. Enzymes are living bacteria that spend their lives snacking on your stain. It takes time for them to eat it, and they may die before they finish because they have a relatively short lifespan.

    With enzymes, you apply them and keep checking back every few hours. The stain should fade, and you will need to reapply it every 24 hours until it’s gone.

    woman washing cleaning tile floor with spray and gloves
    Image credit: etonastenka, Shutterstock

    What Is the Benefit of Enzyme Cleaners?

    Many stains can penetrate the fabric and become locked, unable to be dislodged by traditional detergents. These detergents frequently contain chemicals that can be harmful to your pet or yourself. Enzymes, on the other hand, are microscopic living bacteria that will eat the stain before dying. These bacteria are not harmful to people or pets, and they have a short lifespan. They don’t create any odor or leave any residue behind that you need to rinse.

    What Makes One Brand Better Than Another?

    The primary thing that makes one brand better than another is the concentration of enzymes in the bottle. As the enzymes eat, they die, so if there are only a few, you will need to reapply it several times before your stain comes out. Unfortunately, there is no way to tell how concentrated most brands are, so you will need to resort to trial and error, and reviews like these. Since many brands have limited ingredients, you can often guess the concentration based on cost.

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    Final Thoughts

    When choosing your next enzyme cleaner, we highly recommend our pick as the best overall. Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray provides you with a highly versatile enzyme cleaner. The no-mix solution is more than suitable for most pet owners that have new or set-in accidents that require immediate clean-up. If your pet rarely has an accident and you are looking for something small for a single accident, we recommend our pick for the budget buy. The PetSafe Pet Loo Wee Care Enzyme Cleaner comes in a small eco-friendly package and should eliminate your stain or odor without breaking the bank.

    We hope you have enjoyed reading over these reviews and found them helpful in answering your questions. If you have found a few brands you would like to try, please share these 8 best cat urine and odor removers on Facebook and Twitter.

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