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Home > Rodents > 11 Best Rat & Mouse Urine Cleaners in 2024 – Reviews & Top Picks

11 Best Rat & Mouse Urine Cleaners in 2024 – Reviews & Top Picks

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Rat and mouse urine can be a challenging problem to clean. The urine contains ammonia which can cause several health issues, including asthma and other respiratory problems, so it’s important to clean the urine as soon as possible to prevent any long-term damage.

Luckily, there are several products available that can help clean rat and mouse urine. In this article, we will be discussing the best rat and mouse urine cleaners for the year and giving you a rundown of what to expect from each product. Rat and mouse urine can be difficult to clean up, but with the right product, it can be done quickly and easily. So, without further ado, let’s get started!

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A Quick Comparison of Our Winners in 2024

Image Product Details
Best Overall
Winner
Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator
  • Neutral scent
  • Uses bio-enzymes to eliminate stains and odors
  • Can be used on most surfaces
  • Budget Buy
    Second place
    Urine Gone Pet Stain & Odor Eliminator Urine Gone Pet Stain & Odor Eliminator
  • Works on all surfaces
  • Deeply penetrates material fibers
  • Breaks down urine odor rather than covering it up
  • Third place
    Ion Fusion Severe Pet Urine & Odor Destroyer Ion Fusion Severe Pet Urine & Odor Destroyer
  • Spray bottle is ergonomically designed
  • Contains naturally derived, non-toxic ingredients
  • You get 100% more spray with the refill cartridge
  • Simple Solution Pet Urine Destroyer Simple Solution Pet Urine Destroyer
  • Carpet and Rug Institute-approved
  • It can be used on water-safe surfaces
  • Designed not to damage colorfast carpets
  • Urine Gone Stream Clean Pet Stain & Odor Eliminator Spray Urine Gone Stream Clean Pet Stain & Odor Eliminator Spray
  • No need to scrub
  • Point and spray mechanism
  • Eliminates many different kinds of stains
  • The 11 Best Rat & Mouse Urine Cleaners

    1. Hepper Bio-Enzyme Pet Stain & Odor Eliminator Spray – Best Overall

    hepper enzyme cleaner spray

    The Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray is the best overall urine cleaner for rat and mouse urine. This product can be used on carpets, hard floors, furniture, and many fabrics. It doesn’t just clean urine but also uses enzymes to bind to, lift, and remove odors and stains, including set-in stains.

    It has a neutral scent that won’t overwhelm your space and won’t simply cover urine odors. It also shouldn’t negatively impact the sensitive respiratory systems of pets, like cats, dogs, and rats. It can be used to clean more than urine as well, working well on stains and odors left behind by feces, vomit, drool, and food.

    It comes in a 32-ounce bottle that will last a long time due to its efficacy. Best of all, Hepper sells this product with a 100% satisfaction guarantee. As with most enzymatic cleaners, this product may remove the color from certain fabrics. Make sure to test it in an inconspicuous area before use.

    At PetKeen.com, we’ve admired Hepper for many years and decided to take a controlling ownership interest so that we could benefit from the outstanding designs of this cool pet company!

    Pros
    • Can be used on multiple floor, furniture, and fabric types
    • Uses enzymes to clean stains and odors
    • Neutral scent that isn’t overwhelming
    • Large bottle size
    • 100% satisfaction guarantee
    Cons
    • May take color out of some fabrics

    2. Urine Gone Pet Stain & Odor Eliminator – Budget Buy

    Urine Gone Pet Stain & Odor Eliminator

    Pet type: All pets
    Mechanism: Spray

    Urine Gone Pet Stain & Odor Eliminator is an enzyme-based solution that penetrates deep into fibers, breaking down odors and removing stains. This odor eliminator may be applied to carpets, wood, tiles, bathrooms, sofas, beds, and even cages. It is completely non-toxic, so you are able to use it on both rat and mouse urine and other pet accidents.

    The enzymes contained in this product help to remove odors and stains right at the source. It instantly penetrates deep into the fibers of the fabric to remove odors and stains. This product is significantly cheaper than many other of our top-rated products and is the best rat and mouse urine cleaner for the money.

    Pros
    • Enzymes help eliminate stink and stains at their source
    • Deeply penetrates material fibers
    • Works on all surfaces
    • Breaks down urine odor rather than covering it up
    • Safe for people and rodents
    Cons
    • Some people do not enjoy the fragrance of the new formula

    3. Ion Fusion Severe Pet Urine & Odor Destroyer

    Ion Fusion Severe Pet Urine & Odor Destroyer

    Pet type: All pets
    Mechanism: Spray

    You can give tough rat and mouse messes a run for their money with Ion Fusion Severe Pet Urine & Odor Destroyer. It won’t fade over time and won’t bleach surfaces either. In fact, it works quickly to remove tough stains and stinky rodent odors, leaving behind a pleasant blueberry scent. As the name implies, the product is designed to remove stains caused by urine, feces, blood, vomit, oil, grease, wine, and food.

    In addition to being biodegradable and non-toxic, this spray is suitable for your furry friends as well. Each bottle comes with a refill cartridge that doubles the amount of cleaning power. With an ergonomically designed spray bottle, every drop of liquid is distributed evenly.

    Pros
    • You get 100% more spray with the refill cartridge
    • Instantly removes stains caused by urine, feces, and more
    • Contains naturally derived, non-toxic ingredients
    • Spray bottle is ergonomically designed
    • Mixed berry scent
    Cons
    • Some users dislike the scent

    4. Simple Solution Pet Urine Destroyer

    Simple Solution Pet Urine Destroyer

    Pet type: All pets
    Mechanism: Spray

    Get rid of accidental urine stains from your rodent pal with Simple Solution Pet Urine Destroyer. The enzymes in this pet urine odor remover help eliminate the cause of tough urine stains and discourage repeat accidents. It can be used on carpets, upholstery, bedding, fabric toys, clothing, and other water-safe surfaces throughout your home.

    This pet urine odor remover has an easy-pour cap for refilling sprayer bottles and is designed to not damage colorfast carpets. Applied as directed, it is approved by the Carpet and Rug Institute and is safe for use around rodents.

    Pros
    • Removes rat and mouse urine odor
    • Carpet and Rug Institute-approved
    • Designed not to damage colorfast carpets
    • Formed with enzymes that help eliminate tough urine stains
    • It can be used on water-safe surfaces
    Cons
    • It has an initially unpleasant scent that fades after a while
    • You need to refill your own sprayer bottle

    5. Urine Gone Stream Clean Pet Stain & Odor Eliminator Spray

    Urine Gone Stream Clean Pet Stain & Odor Eliminator Spray

    Pet type: Rat, mouse, gerbil, rabbit, guinea pig, chinchilla, hamster, ferret, hedgehog, sugar glider
    Mechanism: Shake and spray

    Whenever you have a pet rat or mouse, accidents are bound to happen, no matter how careful you are. Fortunately, Urine Gone Stream Clean Pet Stain & Odor Eliminator Spray is designed to remove tough stains and odors at the source. An enzyme-based solution that’s been featured on TV, it comes in an 18-ounce bottle, and rat and mouse urine stains, grape juice, coffee, wine, ketchup, and other tough household stains can be easily removed with the spray nozzle—no scrubbing necessary.

    No longer do you have to bend down and scrub out tough stains. Simply point the nozzle at the soiled area and spray. This product cleans deep to remove difficult stains caused by rat and mouse urine. It contains enzymes that help eliminate odors and stains at their source.

    Pros
    • No need to scrub
    • Point and spray mechanism
    • Eliminates many different kinds of stains
    • Stains and stink are removed at the source by enzymes
    Cons
    • May require repeat applications to work

    6. ECOS for Pets! Stain & Odor Remover

    ECOS for Pets! Stain & Odor Remover

    Pet type: Rabbit, chinchilla, gerbil, hamster, ferret, hedgehog, mouse, rat, degu, sugar glider
    Mechanism: Spray

    ECOS for Pets is environmentally friendly and means business when it comes to rodent messes. It removes stains and odors with a special formula that is derived from plants to clean up just about anything left behind by your rat or mouse. It comes from the leading brand of eco-friendly cleaning products with powerful enzymes that work effectively and safely to lift stains and remove odors, regardless of whether your rodent had an accident or an upset stomach.

    Since it’s completely non-toxic, your rat or mouse can run free immediately after cleaning, so one quick spray and you’re back to having fun.

    Pros
    • Cleans with plant-derived cleaning agents
    • Works on feces, urine, blood, vomit, and other organic messes
    • Made in the USA with non-toxic ingredients
    • Safe on rugs, carpets, upholstery, and clothing
    • ECOS is a leading brand in green cleaning
    Cons
    • Works better on stains than on odors

    7. Shop Care Super Enzyme Pet Urine & Odor Destroyer

    Shop Care Super Enzyme Pet Urine & Odor Destroyer

    Pet type: All pets
    Mechanism: Spray

    The Shop Care Super Enzyme Pet Urine & Odor Destroyer was developed to eliminate rat and mouse odors as well as urine odors. The professional-level cleanser is biodegradable and non-toxic, making it ideal for all areas rats and mice congregate—indoors and outdoors. It is perfect for use on artificial grass, gravel, and grassy areas surrounding trees, pavements, walls, and walkways.

    The odor blaster is also effective for home use, including carpeted areas, rodent bedding, cages, and furniture. It is a necessary tool for every pet professional and rat or mouse parent.

    Pros
    • Suitable for use in cages
    • Great for deodorizing the strongest smells
    • Eliminates urine odors
    • Can be used indoors and outdoors
    Cons
    • Does not come with a sprayer

    8. Shout Pets Oxy Urine Destroyer for Carpeting & Upholstery

    Shout Pets Oxy Urine Destroyer for Carpeting & Upholstery

    Pet type: All pets
    Mechanism: Spray

    With the Shout Pets Oxy Urine Destroyer for Carpeting & Upholstery, you can ensure a deep clean for your carpets, fabrics, and upholstery. The product relies on its proprietary, urine-destroying formula that targets and breaks down urine on contact and penetrates deep into the fabric layers to eliminate all stains and odors.

    Designed with a specialized-strength, deep-cleaning action, it uses the power of oxygen to get rid of even the toughest urine stains and odors—such as well-established, long-term stains. Plus, it is gentle enough to keep your fabrics smelling great and looking good. Apply the deep-cleaning formula to soiled areas, let it penetrate, let it dry, and then vacuum.

    Pros
    • Breaks stains and odors down on contact
    • Won’t damage carpets and fabrics
    • Eliminates odor-causing bacteria
    • A fresh-scent formula made in the USA
    Cons
    • Contact with skin may cause an allergic reaction

    9. Skout’s Honor Outdoor Urine & Odor Destroyer Spray

    Skout's Honor Outdoor Urine & Odor Destroyer Spray

    Pet type: All pets
    Mechanism: Spray

    With Skout’s Honor Outdoor Urine & Odor Destroyer Spray, you can keep both indoor and outdoor spaces in your home, office, or pet facility in pristine condition. Its powerful formula quickly breaks down stubborn stains and eliminates smelly odors from cages, flooring, concrete, brick, artificial turf, outdoor furniture, and other places you enjoy spending time with your rat or mouse. The best part is that this eco-friendly cleaner is made in the United States.

    Pros
    • Made in the United States
    • The formula breaks down urine
    • Effortlessly eliminates odors
    • Deep cleaning
    • Eco-friendly
    Cons
    • Contact with eyes causes irritation
    • Must be used in a well-ventilated space

    10. Tough Stuff Urine Odor & Stain Eliminator

    Tough Stuff Urine Odor & Stain Eliminator

    Pet type: All pets
    Mechanism: Spray

    Rat and mouse owners know that accidents do happen and when they do, the Urine Odor & Stain Eliminator from Tough Stuff will help you clean up in a jiffy. This advanced biological solution is made in the USA and contains ingredients that break down and eliminate unpleasant smells from the source. Therefore, you don’t have to worry about odor masking with this formula. Besides being effective against some of the toughest urine stains, it can also be used on practically any surface that is water-safe.

    Pros
    • Stains and stink are banished by an enzyme-producing process
    • It works on any water-safe surface
    • The Carpet and Rug Institute (CRI) Seal of Approval
    • Urine-specifically
    • Made in the USA
    Cons
    • Must be kept out of the reach of children

    11. ZORBX Pet Urine Stain & Odor Remover

    ZORBX Pet Urine Stain & Odor Remover

    Pet type: All pets
    Mechanism: Spray

    In the event that you need to clean up rat or mouse messes around your home quickly, reach for ZORBX Pet Urine Stain & Odor Remover. With its powerful natural enzyme formula, this cleaner helps eliminate rodent urine odors as well as eliminates urine stains. You can use it on any surface, in your rodent’s cage, and even on carpets and upholstery, without any problems. Even better, there is no mixing required—it is ready for use straight out of the bottle.

    Pros
    • Made in the United States
    • It doesn’t just mask odors
    • Safe and effective
    • No mixing required
    • Safe for carpets and upholstery
    Cons
    • Treated areas must dry completely

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    Buyers Guide: Choosing the Best Rat & Mouse Urine Cleaners

    How Do You Get Rid of Rat & Mouse Urine Smells?

    One possible way to remove the smell of rat or mouse urine is by using an enzyme cleaner. These cleaners work by breaking down the proteins in the urine, which then eliminates the smell. Another way to remove the smell is by using a baking soda and water mixture. Baking soda is a natural deodorizer, so it can help to get rid of smells from urine, as well as other odors.

    Finally, another option is to use a vinegar and water mixture or to clean the area with a mixture of one part bleach to nine parts water. You can also use one of the commercial cleaners reviewed above, which are specifically designed to remove these odors.

    Will Rat Urine Smell Go Away?

    In general, a rat urine smell will not go away on its own. It is important to clean the area where the rat urine was left as soon as possible to prevent the smell from getting worse. If the smell is strong, using a cleaner will help get rid of the odor. Whether or not a rat urine smell will go away depends on a number of factors, including the severity of the smell and the type of surface it is on.

    In some cases, a rat urine smell may dissipate over time, but in other cases, it may become more entrenched. The best way to get rid of a rat urine smell is to identify and eliminate the source of the smell.

    woman cleaning carpet
    Image Credit By: Pixel-Shot, Shutterstock

    What Does Mouse 0r Rat Pee Smell Like?

    The urine of a mouse or rat smells like ammonia. This is because they produce high levels of the compound urea in their urine, which has a strong ammonia smell. The urine of other animals, such as humans, does not have this strong ammonia smell because it produces much lower levels of urea.

    Can Rat Pee Make You Sick?

    There is a great deal of uncertainty surrounding the potential health risks associated with rat urine. Some researchers suggest that rat urine may contain harmful bacteria and toxins that could make someone sick if they are exposed to it. However, there is not much scientific evidence to support this claim, and more research is needed to determine the potential dangers of rat urine. In the meantime, it is probably best to avoid contact with rat urine if possible, just to be safe.

    What Can Be Done to Stop Pet Rats from Peeing Everywhere?

    Litter-training your rat will prevent it from peeing everywhere. If, however, your rat is marking with small drops of urine, this is normal behavior. If it is a problem, there are a variety of ways to solve it. To begin with, you need to understand the difference between peeing and marking. Pet rats can be guided to have better potty-training behaviors based on the reason for their actions.

    What Is the Difference Between Peeing & Marking?

    In order to determine the cause of your pet’s urination outside their cage, you should distinguish between peeing and puddles and marking and droplets. Peeing and marking are two different but interconnected actions that are motivated by different reasons. Puddles occur more frequently when a rat is in pain, frightened, or has taken to peeing in inappropriate places. As rats mark their surroundings with droplets, droplets are a common occurrence.

    Why Is My Rat Peeing Everywhere?

    A puddle of urine on the floor or soaked into your bedding would make anyone unhappy. Remember, however, that the pet rat that left the mess may have been feeling poorly. Rats do not tend to leave large puddles unless they have a full bladder after waking up from a long nap. Significant volumes of urine indicate that the pet rat was frightened or even in pain at the time of the accident. Be sure to comfort your pet rat if this is the case. Putting them back in their cages or providing them with safe places is usually a wise idea, and trying to figure out or remove the offending source of fear will lead to fewer spills in the future.

    Cleaning materials on the floo
    Image Credit By: Mariakray, Pixabay

    Why Is My Rat Leaving Drops of Pee Around the House?

    The rat is likely scent marking, which is a way for the rat to communicate with other rats. Rats use their urine and other secretions to mark territory, identify friends and foes, and send messages of sexual interest. Males will often mark more frequently than females. You may also see the rat licking or chewing on objects in order to spread their scent.

    How Can I ​​Reduce Pet Rat Peeing and Marking Behaviors?

    There are a few things that rat owners can do to help reduce their pet rat’s peeing and marking behaviors. One is to keep the rat’s living space clean, free of any strong smells, and provide plenty of toys and hiding spots. Rat owners can also try training their rats to use a litter box, which can help reduce the amount of urine marking behavior.

    How Can I Litter Train a Pet Rat?

    There are a few different ways to litter train a pet rat. One way is to place a litter box in the corner of the rat’s cage and put some bedding in it. Rats will usually start to use the box once they get used to it. Another way to litter train a rat is to put some bedding in a small container and place it near where the rat spends most of its time. The rat will eventually start using the bedding as a bathroom.

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    Conclusion

    In conclusion, rat and mouse urine cleaners are an effective and affordable way to remove urine from various surfaces. To keep your home smelling fresh, try to tackle any accidents quickly, as even hard surfaces can be porous. In particular, soft furnishings need prompt attention. Once rodent pee soaks into these, they can be difficult to de-stain and deodorize. For the best results, be sure to follow the instructions on the bottle.

    Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray is our top choice overall, although if you’re looking for something more budget-friendly, Urine Gone Pet Stain & Odor Eliminator is also a great choice.


    Featured Image Credit: MainelyPhotos, Shutterstock

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