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5 Best Antihistamines for Cat Allergies in 2023 — Reviews & Top Picks


Like humans, cats can suffer from allergies that cause problems like itching, sneezing, a runny nose, and watery eyes. Cats with severe allergy reactions could even start to lose hair and develop bald spots as time goes on. Their fur can get dry and frail, and they may seem lethargic at times. As a cat parent, seeing your furry family member suffer from allergies likely makes you feel lousy too.

Fortunately, your kitty does not have to suffer from allergies throughout the year. There are many antihistamine products on the market that are designed just for cats. These products can help relieve mild to severe allergy symptoms and keep you out of the veterinarian’s office. But which antihistamines for cats are the best?

We put together a list of reviews for the top five antihistamines for cat allergies on the market. Hopefully, the information that we share here will help you easily find the best antihistamine option for your furry family member.


A Quick Comparison of Our Favorites

Image Product Details
Best Overall
HomeoPet Feline Skin and Itch HomeoPet Feline Skin and Itch
  • Works for kittens and adult cats alike
  • Made with all-natural ingredients
  • Easy to store and manage
  • Best Value
    Second place
    Pro-Sense Itch and Allergy Solutions Pro-Sense Itch and Allergy Solutions
  • Fast-acting formula
  • Itching and sneezing relief year-round
  • Comes in many forms
  • Premium Choice
    Third place
    BiologicVET BioSKIN&COAT Powder BiologicVET BioSKIN&COAT Powder
  • No artificial Ingredients
  • Helps regulate hormones
  • Made in USA
  • Paws & Pals Dog Allergy Relief Paws & Pals Dog Allergy Relief
  • Seasonal and year-round allergy relief
  • With natural antioxidants
  • Minimize hairloss
  • BestLife4Pets Healthy Skin and Allergy Relief BestLife4Pets Healthy Skin and Allergy Relief
  • All-natural ingredients
  • Minimize patchy balding
  • Strengthens immune system
  • The 5 Best Antihistamines for Cat Allergies — Reviews 2023

    1. HomeoPet Feline Skin and Itch — Best Overall

    HomeoPet Feline Skin and Itch

    This temporary relief formula helps stop itching, gnawing, and balding due to allergic reactions in your cat. It works to detoxify the body and skin to prevent allergies from sticking around and enhance the health of the skin and coat. HomeoPet Feline Skin and Itch can work for acute allergic reactions, which can help you avoid a trip to the emergency veterinarian’s office.

    This product is safe enough for use on kittens due to the incorporated natural ingredients. This antihistamine includes no harsh chemicals and is not linked to any side effects, which makes us feel confident in using it regularly throughout allergy season. You can expect to get up to 90 doses per bottle, which offers outstanding value compared to some similar options on the market.

    This is a liquid formula that is administered through an included dropper. The medicine can be administered right into a cat’s mouth or added to their food just before mealtime, depending on the owner’s preferences. The packaging is self-containable and easy to store, making this product a convenient option for busy cat owners who do not have time for planning and prepping.

    • Provides immediate temporary relief when necessary
    • Works for kittens and adult cats alike
    • Made with all-natural ingredients
    • Easy to store and manage
    • Some cats may not eat food that is infused with this formula, so it must be hand-administered

    2. Pro-Sense Itch and Allergy Solutions — Best Value

    Pro-Sense Itch and Allergy Solutions

    Pro-Sense Itch and Allergy Solutions is the best antihistamine for cat allergies for the money because it offers fast relief at an affordable price and does not lag in terms of effectiveness. While it will not relieve major allergy symptoms, like balding, it will relieve scratching and gnawing that can cause skin irritation and hair loss over time.

    Sneezing and runny noses can be controlled with the help of this cat antihistamine formula. It comes in many application varieties, including spray, shampoo, and pills, to make administering the formula easy and convenient for everyone. Unfortunately, this brand does include artificial coloring, which is not necessary and could cause side effects.

    • Fast-acting formula
    • Offers itching and sneezing relief year-round
    • Comes in many forms, including spray, pill, and shampoo
    • May not be suitable for kittens
    • Made with artificial ingredients

    3. BiologicVET BioSKIN&COAT Powder — Premium Choice

    BiologicVET BioSKIN&COAT Powder

    This antihistamine formula offers relief for cats with seasonal allergies and hotspots or yeast overgrowth throughout the year. Being made with natural ingredients like lignan-rich biofiber helps optimize the absorption of nutrients and enhance hormone functionality for cats that have been spayed or neutered. This formula is made in the United States and meets the National Animal Supplement Council standards overall.

    There are no artificial flavors, colors, or preservatives to worry about, and because it is free of binders, you can have peace of mind knowing that any dose that you administer to your cat will be a healthy one. This formula includes real ingredients, like sunflower and sesame seeds, flax, and natural prebiotics, to replenish nutrients and help the immune system fight off allergy attacks. However, this option is more expensive than the others on our list, and it must be carefully stored to maintain its integrity.

    • Does not contain any artificial ingredients
    • Helps regulate hormones
    • More expensive than other options on our list
    • More difficult to store and maintain than the average option

    4. Paws & Pals Dog Allergy Relief

    Paws & Pals Dog Allergy Relief

    These seasonal chew treats are tasty and easy to feed to most cats, making them a great addition to mealtimes all year long. When fed to cats regularly, Paws & Pals Dog Allergy Relief offers antihistamine relief from general allergies year-round. This formula stops cats from itching and biting themselves and helps control the loss of hair as time goes on.

    This formula also offers a dose of antioxidants to the body so the immune system stays strong and can effectively fight allergens off when necessary. However, this formula likely will not help with bald spots and intense itching episodes. Some cats do not like the chew treats as-is, so they may need to be broken up into wet food.

    • Offers seasonal and year-round allergy relief
    • Formulated with natural antioxidants for extra immune support
    • Some cats do not like the taste or texture of these treats
    • Does not help bald spots

    5. BestLife4Pets Healthy Skin and Allergy Relief

    BestLife4Pets Healthy Skin and Allergy Relief

    BestLife4Pets Healthy Skin and Allergy Relief is an all-natural supplement that helps relieve allergies in cats, while strengthening the immune system so it can help fight off allergens in the first place. This formula not only stops itching and other minor reactions to allergens, but it also helps minimize shedding overall as time goes on.

    This formula helps minimize patchy balding, swelling, and even raised welts that are a result of allergen exposure. It helps balance hormones and nutrient absorption, so cats can better fight off allergens naturally. This formula is known to keep licking to a minimum too. The downsides are that the pills are bitter, so most cats will not eat them unless they are disguised with other food, and the pills are also large, so they can be tough for some cats to chew and digest even if they are willing to take them as-is.

    • Made with all-natural ingredients
    • Relieves itching, shedding, balding, and welts
    • The pills are bitter, which most cats do not enjoy
    • The pills are large and hard to chew for younger or smaller cats

    Buyer’s Guide

    Choosing the right antihistamine for your cat should be about more than reading reviews. There are several other things that you can do to make sure your kitty gets the right kind of medicine for their allergy relief needs. We decided to share our tips and tricks with you to help ensure that you have complete peace of mind when deciding on which antihistamine to invest in for your cat.

    Make a List of Specific Symptoms

    Before you even start looking for an antihistamine to give your cat, it is a good idea to create a complete list of their specific symptoms. Note any sneeze, cough, itch, drool, and sign of discomfort that you witness. If possible, set an alarm to wake up in the middle of the night and check on their symptoms then.

    Does cooler air at night make their allergens more or less powerful? Does sunlight seem to help ease symptoms? What is your cat eating, if anything, before a big allergy attack occurs? Taking notes about everything that you observe will help you figure out exactly what kind of allergy relief your kitty cat needs.

    After you have spent a few days documenting specific symptoms and observations, go back through your writings and determine which symptoms are recurring and which are occasional. You can figure out whether certain areas of the house or time of the day make the allergy symptoms more severe. Having insight into these things will allow you to ultimately figure out what kind of antihistamine medication your cat should try.

    The information that you glean can also help you determine whether home remedies could enhance the effects of antihistamines for your cat. For example, coconut oil can reduce the occurrence of itching and dryness associated with allergies. Apple cider vinegar may also be helpful when it comes to getting your cat healthy enough to fight off allergy attacks. In combination with antihistamines, home remedies can help you dominate your cat’s allergy symptoms once and for all.

    Consider Your Lifestyle

    It is also important to consider your lifestyle and your cat’s preferences before starting a search for cat antihistamine. The formulas come in a variety of forms, with sprays, pills, and liquids being the most popular. If your cat does not enjoy being hand- or force-fed, chances are that you will not want to give them a pill because they likely will not eat it. If you are typically busy during the day, adding a liquid antihistamine to your cat’s food may be your best bet because it is quick and easy.

    If you prefer to treat your cat first thing in the morning before work, you can use a spray to administer the antihistamine directly into your cat’s mouth. If you take your cat on adventures, you may want to invest in the pill form as a mess-free option for on the go. One or more options may be necessary to keep your kitty’s allergy symptoms under control.

    Create a Backup Plan

    You should create a backup plan in case your initial antihistamine choice does not work for some reason. You may find that your cat dislikes the antihistamine that you chose and refuses to ingest it. In this case, you will need to quickly find a different option to help control their symptoms. If you already have a backup to rely on, you can find and administer it to your furry family member.

    Cat scratching close up
    Image Credit By: Comanche0, pixabay

    Ultimately, you should choose two different antihistamine options to begin with, so if one does not work for your kitty, you immediately have another one to fall back on. If possible, buy your first and second choice at the same time to ensure that your cat is well protected in the coming months. You may even want to invest in a third option just in case! If anything, you will have an opportunity to compare the different options to one another by seeing how they work in action.

    Ask Your Friends and Family Members

    It is always a good idea to ask your friends and family members who are cat owners whether they have found effective remedies for allergies. They can provide you with insight into everything from homemade remedies to store-bought antihistamine options. They will let you know all the ways that they have tried feeding antihistamines to their cats, so you can learn from their experiences instead of wasting time figuring it out on your own.

    They can also let you know which antihistamine products they have tried that have not performed as well as expected, so you can avoid those products if possible. But if you don’t know many people who own cats, there is no reason to stress out. You can count on the options presented on our reviews list to have quality ingredients that are highly likely to benefit your cat by reducing their overall allergy symptoms.

    Consult With Your Veterinarian First

    One of the most important things that you can do before choosing a new antihistamine for your kitty is to consult with your veterinarian. Your vet can do blood tests and review your pet’s medical history to determine if there are any ingredients that either you should stay away from or should be looking for. They can also conduct a basic examination to determine if your cat can handle medication and if there are other things that you can do to help relieve your cat’s allergy symptoms in addition to providing them with antihistamine medication.

    Your vet can let you know whether a specific antihistamine medication is right for your cat or whether you should skip an option on your shortlist. In short, they will give you the information that you need to confidently choose an antihistamine that is perfect for your furry pet. If anything, your vet should be happy to provide you with their expected advice about any product that you are considering investing money in.

    Every antihistamine for cats featured on our reviews list is worth your consideration, but we highly suggest the first and second featured choices. HomeoPet Feline Skin and Itch offers immediate allergy symptom relief for kittens and adult cats and is made with all-natural ingredients. We think that Pro-Sense Itch and Allergy Solutions is the best value because it is affordable, safe, and fast-acting.

    No matter which option you choose, we hope that your kitty cat gets allergy relief soon! Which option on our list do you think will provide your cat with the most relief? Let us know your thoughts and opinions in our comments section below.

    Featured Image Credit: Susan-Santa-Maria, Shutterstock

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